Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). Epub 2020 Feb 27. Advertising revenue supports our not-for-profit mission. vomiting. Dizziness. ([2014, Nov -]): 3. discolored urine. Call your doctor for medical advice about side effects. Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture Nitazoxanide - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). Change in color of urine. Call your doctor for medical advice about side effects. These side effects may go away during treatment as your body adjusts to the medicine. 2. This is not a complete list of side effects and others may occur. Available for Android and iOS devices. The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. 500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. P l a s m a. concentrations of tizoxanide have demonstrated dose . Although not all of these side effects may occur, if they do occur they may need medical attention. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, … Portions of this document last updated: Feb. 01, 2020. pregnancy, upcoming surgery, etc. 25. Gastroesophageal Reflux Disease. Tell your doctor if your symptoms do not improve or if they get worse. Wash your hands, scrub your fingernails and shower often. Stomach pain. Call your doctor for medical advice about side effects. ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Nitazoxanide is a light yellow crystalline powder. Nizonide 500 Tablet is used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and Cryptosporidium. Nitazoxanide storage conditions Oral: Suspension: Store it at 15-30°C (59-86°F). Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the redness of the skin. Read the entire detailed patient monograph for Alinia (Nitazoxanide) You may report them to the FDA. However, many people have no side effects or only have minor side effects. Side effects What side effects can occur from Nitazoxanide? You may need to have tests done to check that the infection is cleared. Epub 2012 Mar 17. This site complies with the HONcode standard for trustworthy health information: verify here. However, safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 year of age. Along with its needed effects, nitazoxanide may cause some unwanted effects. Nitazoxanide side effects Central Nervous System- Headache. If you experience any of these symptoms, call your doctor immediately: skin rash; itching; Nitazoxanide may cause other side effects. Adverse events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea. "Product Information. Nitazoxanide side effects. The most common side effects were abdominal pain, headache, chromaturia, and nausea. If you have any unusual effects, contact your doctor or pharmacist promptly. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Call your doctor for medical advice about side effects. 1. Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. A very serious allergic reaction to this drug is rare. Tablet: Store it at room temperature. If you notice any other effects, check with your healthcare professional. Incidence not known. In various animals, the oral LD 50 is higher than 10 g/kg. You may report side effects to FDA at 1-800-FDA-1088. Clin Infect Dis 40 (2005): 1173-80. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." DESCRIPTION. Applies to nitazoxanide: oral powder for suspension, oral tablet. Nitazoxanide Side Effects. This is not a complete list of side effects and others may occur. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Other side effects not listed may also occur in some patients. Drug information provided by: IBM Micromedex. Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. If you notice any other effects, check with your healthcare professional. Side Effects of Drugs, Annual 23 J.K. Aronson, ed. Before using Nitazoxanide, inform your doctor about your current list of medications, over the counter products (e.g. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Mayo Clinic does not endorse companies or products. Dizziness. Trouble Breathing. Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide: Some side effects of nitazoxanide may occur that usually do not need medical attention. Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. These work by stopping the growth of the protozoa that cause diarrhea. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. You may report side effects … Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. Copyright © 2021 IBM Watson Health. Alinia (nitazoxanide)." Full Drug Information. Practice good hygiene to prevent infection of others. Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. Side effects were generally mild. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. RARE side effects. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. Int Immunopharmacol. You may report side effects to FDA at 1-800-FDA-1088. Buy Nizonide 500 Tablet Online. If experienced, these tend to have a Less Severe expression. heartburn. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. All rights reserved. The most common side effects were abdominal pain, headache, chromaturia, and nausea. hives or welts, itching, or skin rash. Placebo-controlled studies. At present, there are no documented drug-drug interactions. All rights reserved. Nitazoxanide is well tolerated when administered in the recommended dose, with reported side effects being no different than placebo. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." There is no information about the presence of nitazoxanide in human milk, the effects on the breast-fed infant, or the effects on milk production. Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Nitazoxanide is a light yellow crystalline powder. These side effects may go away during treatment as your body adjusts to the medicine. Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." A Skin Rash. vitamins, herbal supplements, etc. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This content does not have an Arabic version. Romark Laboratories L.C., Tampa, FL. Antiepileptic treatment was continued. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. Lancet Infect Dis. Although not all of these side effects may occur, if they do occur they may need medical attention. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. doxycycline, metronidazole, Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide, praziquantel. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. You may report side effects to the FDA at 1-800-FDA-1088. trouble breathing. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Upset stomach. Common side effects may include: nausea, stomach pain; headache; or. It is poorly soluble in ethanol and practically insoluble in water. Last updated on Apr 8, 2020. ).Some health conditions may make you more susceptible to the side-effects of the drug. In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… to 4 g with minimal gastrointestinal side effects. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. 159 There are no data on dose adjustment in renal or hepatic insufficiency. Pharmacology Pharmacodynamics. Some side effects may not be reported. What should I watch for? Medically reviewed by Drugs.com. This drug usually has no side effects. Along with its needed effects, a medicine may cause some unwanted effects. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. All drugs may cause side effects. ), allergies, pre-existing diseases, and current health conditions (e.g. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Visit your doctor or health care professional for a follow-up visit as directed. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. Nitazoxanide may cause side effects. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This content does not have an English version. Other, less serious side effects may be more likely to occur. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. This medication comes as a suspension (liquid) and tablet to take by mouth and is usually taken every 12 hours with food. Do not take this medicine if you have a known allergy to it. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.